the E350 with the Triton V10 is a lot more common. One of the earliest examples of the V10 in a Ford vehicle, the first E350 came with the engine in 1997, the same year the engine came out.
The gearbox was originally built just for the ridiculous torque levels of the company's 6.7-liter turbo-diesel, so odds are it should have no problem ... FORD CLASS-EXCLUSIVE V10 GAS ENGINE ...