show that MDM2 times mitosis through self-catalysed ubiquitination and proteasomal destruction, triggering G1 arrest following delays in mitosis associated with chromosome instability and aneuploidy.

A study identified the mutation mechanism LTA chromothripsis in 50% of high-grade osteosarcoma cases, explaining its genomic ...

Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.

The new insights on osteosarcome could, with time, lead to better treatment options and outcomes for patients through more ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...

A new study reveals a mutation mechanism in osteosarcoma, promising advances in treatment and prognosis for this challenging ...

Osteosarcoma is the most common primary cancer of the bone, with a peak incidence in children and young adults. Researchers ...

A major driver of the bone cancer osteosarcoma has been discovered by researchers from UCL, EMBL EBI and the Royal National Orthopaedic Hospital, providing insights that could help to predict cancer ...