Loss of the Y chromosome (LOY) in men, a dynamic mutation linked to aging, impairs immune function and increases risks of ...

In many organisms, aging is a clear risk factor for increased rates of chromosome mis-segregation, the main source of aneuploidy. Here, we report that old yeast mother c ...

In a study that could help scientists better understand and manipulate cell division, RIKEN biologists have engineered ...

A fluorescence light micrograph of breast cancer cell about to divide into two. Chromosomes are stained blue, while the pink ...

Accordingly, defects in chromosome replication are a major driver of the genomic instability observed in cancer cells. To understand the molecular mechanisms by which eukaryotic cells carry out and ...

We expect that our work will lead to a better understanding of the factors that limit replication fork speed, cause replication fork stalling (quickly leading to double-strand breaks), and inhibit ...