University of Massachusetts Chan Medical School, Worcester, MA, United States ...

Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells ... to the contact site and are secreted, thus killing the target. T cells go through different ...

The review then dissects how TAMs manipulate this immune response, further depleting CD8+ T cell functions through mechanisms like arginine deprivation and creating hypoxic environments that lead to ...

Research uncovers how P-stalk ribosomes regulate cytokine responses, driving immune evasion in tumors across multiple cancer ...

A new study from MUSC Hollings Cancer Center researchers shows, for the first time, that a receptor called PPAR δ, or ...

According to researchers, restoring damaged mitochondrial function can enhance the efficacy of immune cells. Nevertheless, the mechanism of mitochondrial dysfunction in immune ... while also being ...

To more efficiently identify these novel mechanisms, investigators co-led ... our B-cell therapies not only can activate tumor-killing CD8 T-cells, but a subset of them can infiltrate the tumor ...

so that no cell gets destroyed if it isn't the proper target of this new killing mechanism. The two proteins in question are known as BCL6, an oncogene which suppresses apoptosis-promoting genes ...

DelveInsight’s Non-Hodgkin Lymphoma pipeline report depicts a robust space with 200+ Non-Hodgkin Lymphoma companies working ...

Neutrophils, macrophages, and CD8+ T lymphocytes are, after all, predictable responders to a sustained noxious insult. However, in recent years something of a renaissance has occurred. COPD ...