It is one of a subset of tumors caused by faulty beta-catenin genes. These beta-catenin-activated tumors—which also include bowel, womb and melanoma skin cancer—all tend to have tumor ...

DPTX3186 is a small molecule c-mod that acts through a novel mechanism of action to sequester beta catenin into nuclear depot ...

“You just can’t reduce something as complex as human exploration to a single gene,” he says, laughing. “Genetics doesn’t work that way.” Fortunately for me, I had to wander only a ...

THRAP3, STMN1, and GNA13—are overrepresented in blood cancers like acute myeloid leukemia (AML) and could prove to be novel ...

which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of ... Novel Treatment Based on Gene Editing Safely and Effectively Removes ...

Think of them as volume knobs for our genes, turning them up or down as needed ... Scientists are exploring ways to use microRNAs or molecules that target them as treatments for various diseases.

The vast majority of human genes -- more than nine in ten -- are edited by the spliceosome. The sheer number of ...

Pierre Vanderhaeghen (VIB-KU Leuven), together with scientists of Columbia University and Ecole Normale Supérieure has discovered a link between two genes, present only in human DNA, and a key ...

The first therapy that uses gene-editing is to be offered on the NHS in a “revolutionary breakthrough” for patients. It will be used as a potential cure for the blood disorder beta thalassaemia.

beta superfamily, and is thought to play a role in the control of metabolism through brown adipose tissue. Transgenic mice in which the gene has been deleted have improved control of blood glucose ...

Gene therapy with elivaldogene autotemcel (eli-cel) consisting of autologous CD34+ cells transduced with lentiviral vector containing ABCD1 complementary DNA (Lenti-D ...