For the study, scientists at Gladstone Institutes in the US created a "chimeric" mice model for studying Alzheimer's. The mouse model not only carries human APOE genes, but the team also transplanted ...

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for ...

New research shows that microglia, which usually clear debris, cause harmful inflammation in the presence of APOE4 protein.

A team of scientists has found that the presence of the APOE4 protein -- the most important genetic risk factor for Alzheimer ...

Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...