Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the ...

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for ...

For the study, scientists at Gladstone Institutes in the US created a "chimeric" mice model for studying Alzheimer's. The mouse model not only carries human APOE genes, but the team also transplanted ...

A team of scientists has found that the presence of the APOE4 protein -- the most important genetic risk factor for Alzheimer ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

It's always a worry if you've spotted a mouse indoors or a rat in the backyard. And learning how to get rid of mice or how to get rid of rats can be a challenging and often expensive task at the ...

近日，来自德国慕尼黑理工大学神经细胞生物学研究所的Mikael Simons教授团队在Cell Press细胞出版社旗下Immunity期刊在线发表了一篇题为“Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding ...