Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with each ...

A team of researchers at Roswell Park Comprehensive Cancer Center, led by Dhyan Chandra, Ph.D., has discovered a new ...

During clathrin-mediated endocytosis, a patch of flat plasma membrane is internalized to form a vesicle. In mammalian cells, how the clathrin coat deforms the membrane into a vesicle remains unclear ...

Receptor pharmacology is the study of the interactions of receptors with drugs/pharmaceuticals and other xenobiotics. A basic tenet of receptor pharmacology is that a drug’s effect is directly ...

Comparative genomics approaches have already shown that the basic mechanistic components that diversify immunoglobulin and T cell antigen receptors, including RAG-1 and RAG-2 homologs, essential ...

the androgen receptor (AR) signaling axis. However ... catenin is a multifunction protein that acts as a transcriptional coactivator and regulator of cell-cell adhesion to promote stemness and ...

The European MCL Network Phase 3 TRIANGLE study, evaluated ibrutinib in combination with induction immunochemotherapy, both with and without an autologous stem cell transplant, followed by 24 months f ...

This paper presents the important discovery that lipid metabolic imbalance caused by Snail, an EMT-related transcription factor, contributes to the acquisition of chemoresistance in cancer cells.

A perturbation in immune receptor signaling may underlie the increase in autoimmune phenomena in the elderly, particularly those that contribute to the regulation of immune tolerance. Optimal ...

Kisspeptin-10, a decapeptide derived from the KISS1 gene, has emerged as a focal point of research due to its potential role ...