Fred Hutch researchers have done pioneering work in the areas of gene regulation, chromatin organization and cell cycle state, including quiescence. Gene expression is important because a specific ...

Replication-dependent histone mRNAs are present at high levels only ... regulation, the demarcation of heterochromatic boundaries and the epigenetic inheritance of gene expression patterns.

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

Each of the seven levels represents a step-change in technology, capability, and autonomy. The framework expresses increasing opportunities to innovate, thrive, and transform in a data-fueled and ...

‘Cutting edge’ is, for once, a truly apt description when it comes to gene editing – both because ... potential of in vivo genome editing and regulation, together known as genome engineering ...

If this regulation goes awry, it can lead to serious diseases such as cancer, inflammatory diseases, or neurodegeneration. Despite its importance, understanding gene regulation has been very ...

7 “There's chromatin looping, which is the idea that you can have [DNA] folding in three-dimensional space. [This refers to] gene regulation that's dictated by very long-range contacts ... in which ...

These modifications can affect various levels of gene regulation, including transcription, splicing, stability, translation, nucleosome assembly, and chromatin structure, impacting both physiological ...

scientists used a new gene therapy that was shown to reverse the effects of heart failure in a large animal study. In the study, pigs with heart failure were found to have low levels of cardiac ...

Within the ARC, there are orexigenic coexpressing neuropeptide Y/Agouti gene-related protein (NPY/AgRP) and anorexigenic pro-opiomelanocortin (POMC)/cocaine- and amphetamine-related transcript ...

MarketResearch 2 says GenAI’s value in the pharma sector will soar to nearly £1.7 billion GBP ($2.2 billion ... and consistently engaging C-level leadership with these metrics.” ...

In addition, epigenetic modification also controls the regulation and function of T helper cells along with transcription ... Taken together, our study demonstrated that IL-12 directly activated both ...