该研究开发了一种策略，利用从头设计的结合蛋白（de novo-designed binder，DNDB）代替典型的scFv作为肿瘤表面抗原结合域，以增强CAR-T细胞的抗肿瘤潜力。

Here, we have developed a method to insert LT-scFv into the membranes of prokaryotic and eukaryotic cells rapidly and efficiently (Fig. 1). Purified LT-scFvs are brought into contact with cells ...

FMC63, an IgG2a mouse monoclonal antibody, targets CD19. To date, a majority of the reported CART19 trials include the anti-CD19 scFv extracted from FMC63, such as both the FDA-approved CARs ...

CARGO Therapeutics (CRGX) announced that its first abstract on CRG-023 will be presented as a poster at the upcoming 66th American Society of ...

The production capabilities encompass a broad spectrum of antibody formats, including full-length, scFv, Fab, sdAb/VHH, Fc fusion proteins, chimeric antibodies, and bispecific antibodies.