These rRNAs play a role in peptide bond formation and translocation. The rRNA molecules fold into complex secondary and tertiary structures, forming domains and motifs that are essential for ribosome ...

These molecules function to process rRNA molecules, often resulting in the methylation and pseudouridylation of specific nucleosides. These modifications are mediated by one of two classes of ...

University of Chicago scientists have expanded our understanding of snoRNAs, discovering their extensive influence on ...

Dynamic, reversible modifications of DNA and RNA regulate how genes are expressed and transcribed, which can influence ...

A new approach for identifying new cellular RNA targets of snoRNAs uncovered thousands of previously unknown targets ...

They uncovered thousands of previously unknown targets for snoRNAs in human cells and mouse brain tissues, including many that serve functions other than guiding rRNA modifications. Some of the newly ...

function, and regulation. The production of ribosomes begins when RNA polymerase I (Pol I) synthesizes pre-rRNA, a precursor transcript of the mature ribosomal RNA (rRNA) that later becomes part of ...