Large Subunit rRNAs: The large subunit in prokaryotes contains the 23S and 5S rRNAs, while in eukaryotes ... The rRNA structures also provide binding sites for ribosomal proteins, which help stabilize ...

Macrolides bind reversibly to 23S ribosomal RNA (rRNA) of the 50S subunit of bacterial ribosome inhibiting RNA-dependent protein synthesis. Clindamycin (a lincosamide) at subgrowth inhibitory ...