The basic repeating structural (and functional) unit of chromatin is the nucleosome, which contains eight histone proteins and about 146 base pairs of DNA (Van Holde, 1988; Wolffe, 1999).

在每个细胞内，在每个细胞核中，你的持续生存取决于一场极其复杂的舞蹈。蛋白不断地包裹和解开 ...

▎药明康德内容团队编辑  本周，顶尖学术期刊《自然》及旗下《自然-医学》《自然-癌症》《自然-方法》等一系列子刊联手带来一项重磅专题：人类肿瘤图谱网络计划（HTAN）的最近进展。这一计划从2018年启动，旨在为肿瘤及其周边环境构建单细胞分辨率的三维图 ...

Researchers from UAB and Iowa State University have produced the first-ever genome assemblies of two hidden-neck turtle ...

A new study on dogs found that chromatin's spatial structure has a significant role in the evolution of social behavior.

引言转座元件是广泛存在的遗传单位，这些单位在整个进化过程中对原核生物和真核生物的基因组多样性起着关键作用【1,2】。转座元件对人类发育至关重要，在多能性和胚胎发生中发挥着重要功能。此外，转座元件序列也与人类病理学密切相关，特别是在癌症方面，其作为顺式 ...

Although epigenetic phenomena have been observed for over a century, researchers have only started to untangle their underlying mechanism and effects on gene expression. This course provides and ...

cfDNA coverage shows an inverse relationship with both chromatin accessibility and gene expression levels, Using this relationship and machine learning identify patients with cancer.

In the recent KBS 2TV weekend drama 'The Iron Family', the main character's disease 'degenerative rare retinopathy' is ...

(a, b) Live-cell single-molecule imaging of the fully assembled SWI/SNF chromatin remodeler complex reveals distinct modes of diffusion and DNA-binding across different timescales. (c) STAR ...

研究者在一种参与脂肪醛氧化的酶附近发现了一种假定的因果变异，并在酵母中测试了这种基因，以确认其产生色素变化的能力。研究中广泛的生化和遗传学工作有助于人们了解非模式生物的颜色，为未来对鹦鹉和其他鸟类色素沉着的研究打开大门。