A century after Down syndrome was first described, scientists discovered that the root cause of this disorder is a condition called trisomy 21. What strides in research have been made since then?

Keep the tongue from obscuring landmarks. Cleft lip and palate are often seen in infants with Trisomy 13 (Fig 7). Examine the infant's overall tone and reflexes, including the gag and suck reflex.

SINCE the original description of the syndrome of multiple congenital anomalies associated with trisomy of the number 18 chromosome (E-trisomy) by Edwards et al. 1 in 1960 approximately 60 ...

There is also an apparent "bump" in trisomy among teenage girls. This slight increase has also been observed in several studies of Down syndrome, and might reflect a tendency to non-disjoin in the ...