Blander and Medzhitov explored the function of Toll-like receptor (TLR) signaling in controlling the maturation of phagosomes in macrophages and dendritic cells. As the phagosome is the key ...

Yes, the nose is often the first point of initial contact with the microbial world. That was certainly the lesson of COVID and helped to explain all those nasal swabbings.

The upstream signaling pathways leading to activation of autophagy are not known and currently under investigation in our laboratory. Our recent study links autophagy to innate immunity toll-like ...

Activation of TLR signaling by viral ligands establishes primarily antiviral responses. However, certain viral infections develop TLR-mediated detrimental immunity to the host. Many viruses have ...

Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

Despite promising Phase II data, there was no difference in overall survival between the patients who received Canvaxin and the patients who received placebo in the randomized Phase III trial of ...

Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has ...

Focusing on this interconnected network of genes, we use genome editing in primary immune cells, in vivo models, biochemistry, proteomics, advanced imaging techniques, and genomic screens to decipher ...

Depletion of pDCs or inhibition of IFN-α or IL-33-mediated signaling pathways impeded ... pancreatic inflammation is initiated by a toll-like receptor 3 (TLR3) ligand (poly(I:C)), studies have ...

NEW YORK, Oct. 23, 2024 (GLOBE NEWSWIRE) -- Indaptus Therapeutics, Inc. (Nasdaq: INDP) announced today that Jeffrey A. Meckler, Chief Executive Officer, will present at two upcoming investor ...