In the future, it will be interesting to determine whether activation of the TBK1 signalling pathway can also boost the immunogenicity of other vaccines.

Thus, the expansion of novel targeted therapeutic trials directed against downstream KRAS signaling pathways ... are being combined with BCL-XL, JAK/TBK1 and CDK4 inhibitors.

Co-opted pathways required by oncogenic KRAS in order to sustain lung tumorigenesis Cytokine signaling and its associated ... being combined with BCL-XL, JAK/TBK1 and CDK4 inhibitors.

A protein called STING, previously shown to control a pathway that contributes to antiviral signaling ... More information: ...

cGAMP binds to Stimulator of Interferon Genes (STING) which triggers phosphorylation of IRF3 via TBK1. IRF3 can then go to the nucleus to trigger transcription of inflammatory genes. This pathway ...

TBK1 is a signaling molecule that is activated by receptors when a viral infection occurs. Scaffold proteins do the important job of regulating key signaling pathways. However, up to this point, ...