Synaptic vesicle docking and fusion are mediated by the assembly of a stable SNARE core complex of proteins, which include the synaptic vesicle membrane protein VAMP/synaptobrevin and the ...

In the case of the synapse, the identification and characterization of synaptic protein components and complexes has led to remarkable advances in our understanding of synaptic physiology and function ...

Specific brain cells known as layer 5 pyramidal neurons play a vital role in how our brains process information. Research by ...

Specific brain cells known as layer 5 pyramidal neurons play a vital role in how our brains process information. Research by ...

Layer 5 pyramidal neurons, crucial for brain information processing, vary significantly in their synaptic protein composition based on neuron type.

Peptides have emerged as powerful tools in modern research, providing insight into diverse biological processes and potential ...

Specific brain cells known as layer 5 pyramidal neurons play a vital role in how our brains process information.

Researchers used proteomics to map synaptic proteins in two types of pyramidal neurons, IT and PT, highlighting differences ...

"Cannabis appears to disrupt the brain's natural process of refining and pruning synapses, which is essential for healthy ...

Using cryo-electron tomography, the team was able to visualize synaptic vesicles (SVs) in 3D and confirm a potentially important protein-protein interaction. They also broadened our understanding ...

"I work on a specific protein called SNAP-25," says Bhasne. "Without SNAP-25, the SNARE complex, which is responsible for guiding the synaptic vesicle to the right docking points on the ...