With base substitution mutations, only a single nucleotide within a gene sequence is changed, so only one codon is affected (Figure 1). Insertions and deletions are two other types of mutations ...

Researchers from the University of Illinois have discovered a key factor responsible for facilitating signal transduction in Cys-loop receptors, providing insight into a longstanding question in the ...

They then introduced mutations, triggering changes in the part of HA that directly interacts with receptors. They found that ...

with epidermal growth factor receptor exon 19 deletions or exon 21 L858R substitution mutations, as detected by an FDA-approved test, the company said in a statement. Lung cancer is the leading ...

Other mutations are Val690Met and Val968Met. In Mediterranean peoples, the most common mutation is a C563T substitution resulting in an amino acid change (Ser188Phe). Cases of drug-induced ...

Tagrisso has been recommended for approval in the European Union for the treatment of adult patients with locally advanced, unresectable non-small cell lung cancer, or NSCLC, whose tumors have ...