Nature2mon
The Rho Pathway Mediates Transition to an Alveolar Type I Cell Phenotype During Static Stretch of Alveolar Type II Cells
Rho inhibition. Y27632, a selective Rho kinase (ROCK) inhibitor (Tocris, Ellisville, MO) was added to cells at a concentration of 20 μM/mL, 1 h before stretch and maintained throughout the ...
ALS News Today3d
Phase 2 trial of ROCK inhibitor Bravyl now fully enrolled
A Phase 2 trial testing oral ROCK inhibitor Bravyl in people with ALS is now fully enrolled at its highest dosing group.
Nature4y
Transforming treatments for neurotrauma and neurovascular disorders
BioAxone’s broad pipeline of drugs targets different points in Rho/Rho kinase (ROCK) signaling and related pathways, which play key roles in serious conditions such as spinal cord injury ...
Hosted on MSN5mon
Targeting TGFβ/ROCK2/YAP signaling axis to enhance drug delivery in fibrotic pancreatic cancer
"Initially, we assessed the impact of blocking the transforming growth factor-β (TGFβ) and Rho-associated kinase (ROCK) pathways on ECM remodeling and tissue permeability within our 3D fibrotic ...