癌症，是一种由于体内细胞异常增殖引起的疾病。尽管 癌细胞 来源于自身，但它们依然可以成功躲避免疫系统的识别，逃脱其监视，进而失控生长。这种复杂的逃逸过程使得免疫系统在应对癌细胞时面临巨大挑战。而在过去十年间，研究者们开始关注肿瘤微环境（Tumor ...

Fibroblastic reticular cells (FRCs) create T-cell-supportive niches within lung cancer tumors, facilitating T-cell migration, ...

作者发现，发现表达 CCL19 的成纤维网状细胞（FRC）在人类非小细胞肺癌中产生了相互连接的 T 细胞环境，包括三级淋巴结构和 T 细胞轨道。他们发现，FRC 在肿瘤内形成相互连接的网络，创造出专用的微环境壁龛，T 细胞聚集在那里有效地攻击 癌细胞 。

11月19日Cell最新的研究“Fibroblastic reticular cells generate protective intratumoral T cell environments in lung cancer”，发现成纤维网状细胞（Fibroblastic Reticular Cells ...

Gallen in Switzerland, and his colleagues investigated cells called fibroblastic reticular cells, known to aid communication between immune cells. The team measured gene activity in individual ...

LTβR –induced non-canonical NFκB activation in various stromal subsets within the SLOs is obligatory for the full differentiation of marginal reticular cells (MRC), follicular dendritic cells ...

In our lab, we focus on clathrin-mediated endocytosis, the predominant route for membrane internalisation in most cells. In addition to its role in endocytosis, the clathrin machinery also forms ...