is two-fold. First, in a target discovery mode, RNAi has proven powerful for identifying unexpected pathway components in many normal and disease processes. How likely is it that one could produce ...

The RNAi pathway was first discovered in Caenorhabditis elegans; injection of double-stranded (ds) RNA into the worm initiated sequence-specific degradation of mRNAs that contain the same sequence ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

I shall present recent findings from my lab and collaborators revealing a distinct form of mammalian antiviral response directed by the RNA interference (RNAi) pathway. In the first part of the ...

Plus Oceans Healthcare adds five states with acquisition and UTA professor leads $1.8 million study.

The company's Targeted RNAi Molecule (TRiM ... a ligand and ARO-ALK7 inhibiting a receptor to intervene in a known pathway that signals the body to store fat in adipose tissue.

ARO-INHBE targets a known pathway that signals the body to store ... the company’s investigational RNA interference (RNAi) therapeutic being developed as a potential treatment for obesity.