Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya ... elucidating the unique biochemical requirement for a 2’-PO 4 in the ligation step of ...

The pathogenic mechanism is disruption of developmentally regulated RNA processing, primarily alternative splicing, in which failure to express adult splicing patterns causes primary features of the ...

We have identified robust networks of coordinated regulation driven by a number of RNA binding proteins that make substantial contributions to the physiological transition from fetal to adult tissue ...

has identified novel mechanisms underlying RNA splicing events within glioma tumor cells, mechanisms which may serve as novel therapeutic targets, according to findings published in the Journal of ...

In this webinar, Dr. Megan L Noonan will present her research on the role of alternative splicing in kidney disease ...

RNA-binding proteins (RBPs) play a crucial role in the post-transcriptional regulation of RNA expression, a finely tuned ...

He is a Professor of Structural Biology and Gene Expression at the ICR. Group: Mechanisms and Regulation of pre-mRNA Splicing +44 20 7153 5086 0000-0002-7013-5504 Professor Vlad Pena is a structural ...

The spliceosome in eukaryotes removes non-coding intronic sequences and ligates exons to produce functional messenger ...

Identification of a spliceosome stalled halfway through the catalytic activation (Schmitzova et al., Nature, 2023). Mechanism of the helicase PRP2 in splicing The DEAH helicases are special as they ...

Why is this mechanism crucial for neuronal health ... higher levels of RTP801 can inhibit this complex and cause problems in RNA splicing and subsequent production of relevant proteins, such ...