Researchers unveil the inner mechanisms of the most intricate and complex molecular machine in human biology. Scientists at the Centre (CRG) in Barcelona have developed the first comprehensive ...

During splicing, non-coding segments of RNA are removed ... "This pioneering research illuminates the complex interplay between components of the spliceosome, revealing insight into its ...

Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya ... We recently solved a 2.2 Å crystal structure of the Candida Trl1 kinase domain in complex with ...

Furthermore, many other varieties of RNA have been found to have complex regulatory roles in cells. Thus, RNA molecules play numerous roles in both normal cellular processes and disease states.

The most complex molecular machine in human ... a crucial editing process called splicing. During splicing, non-coding segments of RNA are removed, and the remaining coding sequences are stitched ...

In the context of Alzheimer’s disease, higher levels of RTP801 can inhibit this complex and cause problems in RNA splicing and subsequent production of relevant proteins, such as brain-derived ...

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...

In this webinar, Dr. Megan L Noonan will present her research on the role of alternative splicing in kidney disease progression, discussing how she used nanopore RNA sequencing to accurately detect ...