Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel ...
The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...
Enzymes called protein kinases manage this cycle, which is why mutations or overactivity in these regulatory molecules are particularly implicated in the development of cancer and why kinases are ...
This stage does not require oxygen. If oxygen is available to the cell then the pyruvate molecules can be further broken down in stage two to release more energy and produce a greater quantity of ATP.
With over 15 years of experience in kinase drug discovery, DiscoverX offers the largest collection of nearly 500 biochemical and cell-based kinase assays. KINOMEscan® technology, our novel kinase ...
At any given time in any given cell, multiple types of molecular networks are concurrently active. An important feature of these networks is the multiple reversible reactions of protein ...
Clinical symptoms vary according to the cause of ALF and the age of the child. [4–10] In the newborn, the clinical presentation depends on the etiology of neonatal liver failure. Presentation at ...