and an understanding of how protein kinases function in vivo is therefore of central importance to cell biology. Newly developed protein-kinase inhibitors provide powerful tools for understanding ...

Subsequently, a reactivity function forms a covalent bond ... tool for the isolation of staurosporine-binding kinases from complex protein mixtures. The specificity of the assay is demonstrated ...

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

Varjosalo Lab's longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate ...

Protein tyrosine kinases and protein tyrosine phosphatases coordinate to maintain a protein phospohorylation balance required for normal cell function. If this balance is disrupted, the outcome may be ...

The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family ...

Sino Biological currently sells signaling enzymes, protein kinases, mutant kinases ... Their catalytic function depends on specific conditions, like optimal temperature and pH levels, and involves ...