The Neilson Laboratory studies post-transcriptional regulation of gene expression in human diseases. This is an explanation of what that is and why we do it. The explosion of publicly available ...

This is achieved by specialized tRNA modification enzymes acting alone or as part of complex pathways. These post-transcriptional modifications provide structural integrity to the tRNA molecule and ...

and functional basis for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like proteins such as SUMO, and pathways that contribute to co- and ...