His research focuses on chemical synthesis of artificial oligonucleotides for gene regulation and protein inhibition through the phosphorothioate chemistry.
TLR7 is expressed in plasmacytoid DCs and B cells and is associated with lupus pathogenesis in mice; inhibition of TLR7 by class R INH-ODNs required a nuclease-resistant phosphorothioate backbone ...
As a key player in protein synthesis, mRNA technology is transforming therapeutics, offering solutions for cancer, genetic disorders, and regenerative medicine.