X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for Paget's disease. This situation changed with the development for ...

PRISM (Paget's disease Randomized trial of Intensive versus Symptomatic Management) was a pragmatic randomized controlled trial, designed to compare the effects of intensive bisphosphonate therapy ...

Ipriflavone can block part of the process that leads to bone loss. A bone disease that can cause pain (Paget disease). Early research shows that taking ipriflavone might decrease bone pain in some ...

rapid bone growth and exposure to ionizing radiation can increase the risk of developing this disease. In some cases, the ...