But they were created specifically for ovarian cancers that develop because of mutations on the PTEN ... as a model for ...
indicating that the PTEN–ETS2 pathway is relevant to human breast tumorigenesis. This mouse model, which reflects human breast cancer stroma at both the histological and molecular levels ...
The complex mouse model took several years to develop and characterize but ... They observed that the loss of another tumor suppressor called Pten accelerated this process. At that stage, oncogenic ...