Together with EZH2, SUZ12 and EED, this gene set clearly separated the tumour samples and the normal samples using unsupervised cluster analysis. As the expression status of these PRC2 targets can ...

过去三年里发表的一系列文章——包括朱冰研究组此次发表的这篇文章——都揭示出了H3K27甲基化酶复合体PRC2（Polycomb repressive complex 2）的几种微妙的调节机制，比如这篇文章指出了PRC2在不同紧密程度染色质上的不同活性，表明PRC2能够感知基因的转录状态 ...

As part of PRC2, EZH2 methylates histone 3 at lysine 27 (H3K27), which contributes to transcriptional silencing, thus promoting glycolysis and reducing the expression of MHC in the tumor.

"We then explored the mechanism that might regulate H3K27me1 enrichment and focused on the polycomb repressive complex-2 (PRC2), a ... "Thus, we measured EZH2, SUZ12, and EED protein and RNA ...

10月11日，CDE官网显示，恒瑞医药的EZH2抑制剂SHR2554片申报上市。这是首个申报上市的国产EZH2抑制剂。 SHR2554是恒瑞医药自主研发的新型、高效、选择 ...

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This transcript was prepared by a transcription service. This version may not be in its final form and may be updated. Kate Linebaugh: Last week, Boeing drew up a deal to end a six-week strike ...