During beta-oxidation, fatty acid molecules are broken down by removing two-carbon units from the carboxyl end of a fatty acid molecule to produce acetyl-CoA.

For some time, our work has focused on understanding the roles of acetyl-CoA carboxylases, ACC1 and ACC2, in the regulation of fatty acid synthesis and oxidation as related to energy homeostasis. Our ...

Dr. Wakil demonstrated the requirement of ATP and stimulatory effect of carbon dioxide on fatty acid synthesis from acetyl-CoA, and showed that long-chain fatty acids are synthesized by a system ...