Mice deficient in BACE1 (beta ... appear normal in gross anatomy, tissue histology, hematology and clinical chemistry. BACE1 −/− mice also hemizygous for an amyloid precursor protein (APP ...

Recent studies implicate the immune system and a herpes virus as potential contributors to development of the disease.

All these diseases have in common the expression of a protein outside its normal context, leading to an irreversible change into a sticky conformation rich in beta sheets that make the protein ...

Prions are proteins that function as “seeds” of disease, prompting normal proteins to misfold ... akin to the process by which amyloid-beta and tau proteins accumulate and expand in the ...

For years, researchers have debated the root cause of Alzheimer’s. Two main theories dominate the discussion. The first ...

It is characterized by the accumulation of toxic proteins, such as amyloid beta plaques and tau tangles, which disrupt normal brain function. The blood-brain barrier’s dysfunction has been ...

The newest generation of Alzheimer's therapeutics targets accumulations of the protein amyloid beta with engineered antibodies, but the results have been underwhelming, with some adverse effects ...

Research Background and Objectives The amyloid cascade hypothesis is a leading theory regarding the cause of AD, which states ...