Mice deficient in BACE1 (beta ... appear normal in gross anatomy, tissue histology, hematology and clinical chemistry. BACE1 −/− mice also hemizygous for an amyloid precursor protein (APP ...

is identified by progressive deficits in cognitive and emotional function that are associated with extensive forebrain neuropathology. Several mutations affecting β-amyloid, either to APP 1,2,3 ...

For years, researchers have debated the root cause of Alzheimer’s. Two main theories dominate the discussion. The first ...

The Wake Forest researchers discovered that excessive sugar consumption or high blood sugar levels could increase the ...

Amyloid-beta is a protein fragment naturally produced in the brain during normal cell processes ... in maintaining neuronal health and synaptic function. Its depletion, not its aggregation ...

Much study has focused, now controversially, on abnormal clumps of naturally occurring proteins that increase in Alzheimer's brains as the disease progresses: plaques of amyloid beta ...