In clinical practice, strategies to reduce nephrotoxicity due to specific drugs are usually based on the avoidance of established risk factors, such as high doses. However, effective prevention of ...

One in ten adults suffer from chronic kidney disease (CKD), a condition characterized by progressive loss of kidney function.

This frequently manifests during drug development and/or in standard clinical care. Nephrotoxicity resulting from drug exposure has been estimated to contribute to 19–25% of all cases of acute ...

Caution with immunosuppressants (eg, cyclosporine), other nephrotoxic drugs. Abnormal liver function tests, elevated CPK, respiratory or GI effects, myopathy, cholelithiasis, pancreatitis ...

Increased toxicity with nephrotoxic drugs (eg, NSAIDs). Increased risk for blood disorders, bone marrow failure, and associated complications with azathioprine or 6-mercaptopurine and/or other ...

General measures often employed to prevent or reduce nephrotoxicity include the use of intravenous hydration during drug administration and avoidance of known risk factors, such as high drug doses.