Dowell, L.A. Leinwand and K.S. Anseth, “Extracellullar matrix stiffness controls cardiac valvular myofibroblast activation through ... the development of biomaterials to serve as synthetic ...

Some differentiate into profibrotic macrophages and fibrocytes and increase extracellular matrix deposition ... leading to further fibrocyte and myofibroblast activation and sustained fibrosis ...

Our approach includes the development of synthetic, tunable extracellular matrix mimics ... of mechanotransduction in regulating the myofibroblast phenotype, and (iii) using spatiotemporal regulation ...