U-II was found to increase afterload and reduce myocardial contractility. Its effect at high concentrations is best rationalized by myocardial ischemia. Using the calculations of Sunagawa et al.

Peptides have emerged as a focal point in molecular and biological research, providing a promising avenue for understanding ...

Istaroxime is designed as a positive inotropic agent that increases myocardial contractility through inhibition of Na+/K+- ATPase with a complimentary mechanism that facilitates myocardial ...