The molecule has one shape when ferrying oxygen molecules and a slightly different shape when it is not Its 10,000 atoms are assembled into four chains, each a helix with several bends.

Hemoglobin has played ... paper entitled "Sickle cell anemia: a molecular disease", as it was the first demonstration of "a change produced in a protein molecule by an allelic change in a single ...

In 1961 the structure of one protein, myoglobin, was known at 6 Å resolution and its 2 Å structure would soon be published. The structural determinations of hemoglobin and hen lysozyme were well ...