Methotrexate 300 mg/m 2 by iv. infusion over 12 h Day 2 Etoposide 100 mg/m 2 by iv. infusion over 30 min Actinomycin D 0.5 mg iv. bolus Folinic acid rescue 15 mg orally every 12 h for four doses ...

Methylfolate (also called L-5-MTHF, 5-methyl-folate, L-methylfolate, or 5-MTHF) and folinic acid are in some folate ... with certain medications such as methotrexate, diuretics, NSAIDs ...