We report here that the delivery of leptin to the hypothalamus through intracranial gene transfer results in the efficient normalization of body weights in obese mice, using doses of recombinant ...

This review is part of the "Project ATA," a large, multicenter study using bioinformatics tools to systematically analyze ...

Symptoms include excessive hunger and quick weight gain. Other causes of low leptin levels that do not involve a leptin gene mutation include anorexia nervosa (an eating disorder classified by ...

The scientific interest in the biology of white adipose tissue (WAT) has increased since the discovery of leptin in 1994. The description of the product of the gene obese (ob) demonstrated the ...

Scientists have uncovered a new neuron type, BNC2, which acts quickly to counter hunger-promoting neurons, potentially ...

Hunger" neurons expressing the AGRP gene (red), alongside newly-discovered "satiety" neurons expressing the BNC2 gene (green) ...

In 1994, one of my colleagues at Rockefeller University discovered that the cause of that obesity was the genetic mutation in a gene that makes a previously unknown hormone called leptin.