The challenge was that the key enzyme activity required for this process, known as "Lactyl-CoA mutase," was purely theoretical at first. This activity had not yet been described in nature. Searching ...
The 'lactyl-CoA mutase' can efficiently convert a key metabolic compound into valuable products. To achieve this, the research team used evolution to train the abilities of a natural enzyme in the ...
该成果于2024年12月5日以“Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis”为题发表在Cell Metabolism杂志上 ...