Serum TNF levels following LPS stimulation were also reduced using this gene silencing method. LPS injection is normally lethal, but treatment with siRNA-loaded particles protected mice by ...

Results: We found that at low nanomolar concentrations, treatment of rat primary mesencephalon neuron/glia cultures with CDDO-Me resulted in attenuated LPS-, TNF- or fibrillar amyloid beta 1-42 ...

This study explores the best experimental design for a locally produced neuroinflammation model in adult male C57Bl/6J mice utilizing three stimuli (LPS, BzATP, and LPS+BzATP).