AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...

Erlotinib is a quinazoline derivative that selectively and reversibly inhibits the tyrosine kinase activity of the EGFR. Here, we review the mechanism(s) of action of erlotinib, as well as the ...

Department of Physiology, Division of Life Science, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Japan ...

Contrary to popular belief, antioxidants aren’t a panacea. In fact, recent research in Science suggests that for controlling ...

Targeted therapy revolutionized cancer treatment, with gene fusions leading the way when the FDA approved imatinib in 2001 to ...

The Taiwanese biotech has launched a phase 1/2 trial to test its small molecule cancer therapy in children and young adults ...

Doctors prescribe Rinvoq to treat certain inflammatory conditions, such as Crohn’s disease. A common side effect of the drug ...

This modification regulates the activity, localization, and function of proteins, ultimately influencing various cellular activities. Disruption in these kinase-substrate interactions is often ...

Hematopoietic progenitor kinase 1 (HPK1) is expressed in hematopoietic cells, including T cells, B cells and dendritic cells (DCs). Suppression of HPK1 activity has shown an antitumor effect in ...

Inotuzumab Ozogamicin and Low-Intensity Chemotherapy in Older Patients With Newly Diagnosed CD22+ Philadelphia Chromosome–Negative B-Cell Precursor Acute Lymphoblastic Leukemia We enrolled 16 patients ...