X inactivation turns off entire chromosomes, whereas imprinting turns off only specific genes. How do these processes work, and why do they often produce similar results? Upon examining their ...
Researchers probe how gene imprinting affects the development of distinct species. By crossing two mouse species that normally do not interbreed, Howard Hughes Medical Institute (HHMI) researchers ...
Imprinted genes comprise a small subset of the genome whose epigenetic reprogramming in the germ line is necessary for subsequent normal embryonic development. This reprogramming and resetting of ...
For example, DNA methylation modifies gene expression without altering the nucleotide sequence. A well-studied DNA methylation-based phenomenon is genomic imprinting (ie, genotype-independent ...