The properties of the different IgG isotypes should ... for the original or a different half-molecule and is driven by the relative amounts of both parent antibodies. An excess of either antibody ...

The lead molecule in the NiceR programme is HNSA-5487. Imlifidase is an antibody-cleaving enzyme originating from Streptococcus pyogenes that specifically targets and cleaves immunoglobulin G (IgG) ...

Myasthenia gravis (MG) is an antibody-mediated chronic neuromuscular disorder leading to fluctuating weakness and early muscle fatigue, with limited treatment options available. In MG, such as other ...

IMVT-1402 shows promise in reducing IgG antibodies without increasing LDL ... The IMVT story is basically this: it was running a molecule through trials, and somewhere in the middle of it, the ...

Recent transfusion of immunoglobulin-containing products. The presence of antibodies without viral antigen or DNA. The presence of IgG anti-HBcAb but lack of IgM anti-HBcAb antibody (in our case ...

Objectives Sjögren’s disease (SD) is an autoimmune disease affecting the exocrine glands that is associated with autoantibodies against Ro60/SS-A, anti-Ro52/TRIM21, La/SS-B and others. We examined the ...

Blocking it can reduce circulating immunoglobulin G antibodies, including pathogenic gMG autoantibodies. The double-blind, placebo-controlled trial included 196 adults with a broad range of ...

Maternal antibodies passed across the placenta can interfere with the response to the malaria vaccine, which would explain its lower efficacy in infants under five months of age, according to research ...

2010. Enhanced antibody half-life improves in vivo activity. Nat Biotechnol 28:157-9. PMID: 20081867. 8. Andersen JT, Sandlie I. 2009. The versatile MHC class I-related FcRn protects IgG and ...

Recently, NeoMab Biotechnology (Suzhou) Co., Ltd. (referred to as "NeoMab") launched the innovative NeoMab-IgG Ease model, based on its next-generation ...

Its powerful AbiLeap™ discovery engine combines massively parallel, continuously learning AI with an extensive database of antigen-antibody interactions to generate fully human, IgG-based multi ...