Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...

Entire sections of the chromosome where the repair had taken place were missing ... Gene editing of NCF1 loci is associated ...

论文链接：Rtt105 stimulates Rad51-ssDNA assembly and orchestrates Rad51 and RPA actions to promote homologous recombination repair (pnas.org)。

A new study led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is shedding light on ...

引言DNA双链断裂（DSB）是细胞分裂过程中最严重的DNA损伤类型之一，如果不及时修复，会导致基因突变和癌症。同源重组（HR）是DSB修复的主要途径之一，HR依赖于同源染色体之间的序列匹配，以修复DSB【1】。HR的启动需要先对DSB末端进行DNA端 ...

Unlike its DNA repair role in somatic cells, homologous recombination has a distinct role in meiosis in ensuring proper chromosome segregation. In yeast, an early step of the meiotic program is the ...

PARP1 is critical for repairing DNA single-strand breaks. First-generation PARP1/2 inhibitors have proven effective in the treatment of tumors with mutations in the essential homologous recombination ...

Research led by The University of Texas Health Science Center at San Antonio shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes ...

Pfizer announces positive results from phase 3 TALAPRO-2 trial of Talzenna in combination with Xtandi in patients with mCRPC: New York Friday, October 11, 2024, 09:00 Hrs [IST] Pf ...