and the overexpression of various HDACs in many cancer types, HDAC inhibitors have been extensively investigated as anticancer agents in recent years. “HDAC inhibitors induce cell death in ...

for the treatment of cancer. These include DNA methyltransferase and histone deacetylase (HDAC) inhibitors. Further candidates, including inhibitors of acetyl-lysine readers (bromodomain ...

The cancer evades the immune system by attracting ... In contrast, in the new trial combining an HDAC inhibitor with the immunotherapy, 3 of 27 patients had deep tumor shrinkage from the drug ...

Co. Ltd. has divulged compounds acting as histone deacetylase 1 (HDAC1) and/or 2 (HDAC2) inhibitors reported to be useful for the treatment of cancer.

The cancer evades the immune system by attracting ... In contrast, in the new trial combining an HDAC inhibitor with the immunotherapy, 3 of 27 patients had deep tumor shrinkage from the drug ...

REC-1245 is designed to degrade the protein RBM39, which downregulates cell cycle checkpoints and DNA damage response networks.