Huntingtin was the first disease gene mapped to a specific chromosome. How did scientists do it and what have we learned since then? HD is a rare, adult-onset, autosomal dominant, progressive ...

A research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other neurodegenerative disorders such as ...

HD gene linked to better brain development in early life Huntington's disease is caused by a mutation in the huntingtin (HTT) gene. The protein produced by the HTT gene is necessary for normal ...

This revelation comes from more than 10 years of brain imaging and brain function data, including motor, cognitive, and behavioral assessments, collected from a unique population—children and young ...

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other ...

This review discusses the current and emerging gene and cell therapy strategies for Huntington's disease (HD), a ...

LUTHOR HD 3’mRNA-seq libraries display comprehensive transcription profiles, enabling high-definition gene expression characterization from single eukaryotic cells, cell biopsies, or purified ...

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a mutation in the gene called huntingtin on chromosome 4. HD is inherited in an autosomal dominant fashion, so that each ...