The decision follows a September meeting of the agency's Gastrointestinal Drugs Advisory Committee, which agreed that the ...

Intercept’s US president Vivek Devaraj said the pharma company still believes in the evidence supporting the liver disease ...

Experiments showed that modified Ocaliva activates the farnesoid X receptor (FXR) similarly to Ocaliva but does not activate hX4. In rat models, both the modified and original Ocaliva ...

xenobiotic compounds and microbial byproducts can maintain critical gut immunity by inducing antimicrobial gene expression. FXR: Farnesoid X receptor; VDR: Vitamin D receptor; RXR: Retinoid X ...

Removing a nuclear bile acid receptor that regulates glucose and lipid stability from the intestine blocks gut inflammation ...

When NR1H4/FXR, a nuclear receptor, does not function appropriately in NASH, it can result in bile acid-related liver damage and inflammation. GLP-1R issues in NASH can lead to insulin resistance ...

For the First Trust Industrials/Producer Durables AlphaDEX Fund ETF (Symbol: FXR), we found that the implied analyst target price for the ETF based upon its underlying holdings is $82.85 per unit.

Our lab identified that excessive copper concentrations decreased metabolic nuclear receptor activity (FXR - farnesoid X receptor, HNF4a – hepatocyte nuclear factor, and LRH-1 – liver receptor homolog ...