该药物属于法尼酯 X 受体(Farnesoid X receptor，FXR)激动剂。FXR 是一种在肝脏和肠道中高水平表达的核受体，在胆酸代谢调节中起关键性作用。该药物是 ...

xenobiotic compounds and microbial byproducts can maintain critical gut immunity by inducing antimicrobial gene expression. FXR: Farnesoid X receptor; VDR: Vitamin D receptor; RXR: Retinoid X ...

The decision follows a September meeting of the agency's Gastrointestinal Drugs Advisory Committee, which agreed that the ...

Our lab identified that excessive copper concentrations decreased metabolic nuclear receptor activity (FXR - farnesoid X receptor, HNF4a – hepatocyte nuclear factor, and LRH-1 – liver receptor homolog ...

Experiments showed that modified Ocaliva activates the farnesoid X receptor (FXR) similarly to Ocaliva but does not activate hX4. In rat models, both the modified and original Ocaliva ...

Removing a nuclear bile acid receptor that regulates glucose and lipid stability from the intestine blocks gut inflammation in mice, according to researchers at Children's Hospital Los Angeles.

When NR1H4/FXR, a nuclear receptor, does not function appropriately in NASH, it can result in bile acid-related liver damage and inflammation. GLP-1R issues in NASH can lead to insulin resistance ...