Perturbations of the endoplasmic reticulum (ER) caused by accumulation of unfolded proteins in this organelle trigger signal-transduction responses that assist with restoration of homeostasis ...

The branches of the UPR are mediated by the three endoplasmic reticulum (ER)-resident proteins: inositol-requiring 1 transmembrane kinase/endonuclease 1 (IRE1), pancreatic ER kinase (PERK), and ...

The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance in case ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed -- for instance in ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of ...

We have identified the IRE1/XBP1 branch of the Unfolded Protein Response (UPR) or endoplasmic reticulum (EnR) stress response as a previously unexplored therapeutic vulnerability in MYC-driven breast ...

Inter-organelle communication via the formation of membrane contact sites (MCS) is essential for cell homeostasis. Bacterial pathogens residing in membrane bound vacuoles have exploited this ...